Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | RAF1 | P04049 | 7/20 | 0.61 |
| ▸ | BRAF | P15056 | 5/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.61 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17278101 | 0.95 | SRC (0.66) | EGFRRAF1BRAFMAP2K1SRC | |
| SCHEMBL4023679 | 0.95 | SRC (0.66) | EGFRRAF1BRAFMAP2K1SRC | |
| SCHEMBL5501376 | 0.91 | KDR (0.66) | EGFRRAF1BRAFSRCAURKA | |
| SCHEMBL29631554 | 0.90 | SRC (0.60) | EGFRRAF1BRAFMAP2K1SRC | |
| SCHEMBL4377465 | 0.90 | KDR (0.65) | EGFRRAF1BRAFSRCAURKA | |
| SCHEMBL7211076 | 0.90 | KDR (0.66) | EGFRRAF1BRAFAURKAKDR | |
| SCHEMBL1012845 | 0.90 | BRAF (0.62) | EGFRRAF1BRAFSRCKDR | |
| SCHEMBL7209933 | 0.88 | AURKA (0.59) | EGFRRAF1BRAFAURKAKDR | |
| SCHEMBL19258467 | 0.88 | AURKA (0.62) | RAF1BRAFAURKAKDRFLT4 | |
| SCHEMBL17278095 | 0.88 | BRAF (0.70) | EGFRRAF1BRAFSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |