Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.62 |
| ▸ | RAF1 | P04049 | 9/20 | 0.61 |
| ▸ | BRAF | P15056 | 9/20 | 0.61 |
| ▸ | FLT4 | P35916 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.57 |
| ▸ | TEK | Q02763 | 2/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19258108 | 0.95 | KDR (0.63) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL7211076 | 0.92 | KDR (0.66) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL5501376 | 0.91 | KDR (0.66) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL4377465 | 0.90 | KDR (0.65) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL13680220 | 0.90 | RAF1 (0.62) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL7209612 | 0.88 | EGFR (0.62) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL7209933 | 0.88 | AURKA (0.59) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL19258107 | 0.87 | KDR (0.73) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL19258207 | 0.84 | RAF1 (0.64) | AURKARAF1BRAFFLT4KDR | |
| SCHEMBL17278101 | 0.83 | SRC (0.66) | AURKARAF1BRAFFLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |