Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.61 |
| ▸ | KDR | P35968 | 11/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5958920 | 0.87 | KDR (0.73) | EGFRKDRFLT1ERBB2RET | |
| SCHEMBL7209940 | 0.87 | KDR (0.47) | EGFRKDRFLT1ERBB2RET | |
| Hydrochloric Acid SCHEMBL7209570 | 0.86 | KDR (0.71) | EGFRKDRFLT1ERBB2RET | |
| SCHEMBL7209629 | 0.86 | KDR (0.79) | EGFRKDRFLT1ERBB2RET | |
| SCHEMBL7451507 | 0.84 | MAPK14 (0.51) | EGFRKDRFLT1RETFGFR1 | |
| SCHEMBL7215802 | 0.83 | EGFR (0.55) | EGFRKDRFLT1ERBB2RET | |
| Hydrochloric Acid SCHEMBL7209962 | 0.82 | KDR (0.54) | EGFRKDRFLT1RETFGFR1 | |
| Hydrochloric Acid SCHEMBL7209938 | 0.82 | KDR (0.50) | EGFRKDRFLT1RETFGFR1 | |
| Hydrochloric Acid SCHEMBL7209973 | 0.79 | GAA (0.49) | EGFRKDRFLT1RETFGFR1 | |
| SCHEMBL8713014 | 0.78 | EGFR (0.51) | EGFRKDRFLT1ERBB2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |