Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.51 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | FLT1 | P17948 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | CIT | O14578 | 2/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | STK17B | O94768 | 2/20 | 0.48 |
| ▸ | STK10 | O94804 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | LYN | P07948 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215802 | 0.90 | EGFR (0.55) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL7209940 | 0.84 | KDR (0.47) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL7209619 | 0.78 | EGFR (0.61) | EGFRKDRFLT1FGFR1ERBB2 | |
| SCHEMBL7209951 | 0.77 | EGFR (0.55) | EGFRKDRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL7209962 | 0.77 | KDR (0.54) | EGFRKDRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL7209938 | 0.76 | KDR (0.50) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL7451507 | 0.75 | MAPK14 (0.51) | EGFRKDRFLT1FGFR1RET | |
| Hydrochloric Acid SCHEMBL7209973 | 0.73 | GAA (0.49) | EGFRKDRFLT1FGFR1BRAF | |
| SCHEMBL7214422 | 0.72 | EGFR (0.74) | EGFRKDRFLT1FGFR1FLT4 | |
| Hydrochloric Acid SCHEMBL7209627 | 0.72 | KDR (0.72) | EGFRKDRFLT1FGFR1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |