Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ADK | P55263 | 10/20 | 0.44 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196994 | 1.00 | LMNA (0.55) | LMNAADKP2RY6P2RY14NT5E | |
| SCHEMBL7204488 | 0.89 | LMNA (0.60) | LMNAADK | |
| SCHEMBL8184063 | 0.89 | LMNA (0.60) | LMNAADK | |
| SCHEMBL8196590 | 0.87 | LMNA (0.61) | LMNAADK | |
| SCHEMBL7205800 | 0.87 | LMNA (0.61) | LMNAADK | |
| SCHEMBL3821161 | 0.86 | LMNA (0.56) | LMNAADKP2RY6P2RY14NT5E | |
| SCHEMBL8193744 | 0.85 | LMNA (0.56) | LMNAADKP2RY6P2RY14NT5E | |
| SCHEMBL7210398 | 0.85 | LMNA (0.56) | LMNAADKP2RY6P2RY14NT5E | |
| SCHEMBL3821913 | 0.84 | LMNA (0.76) | LMNAADK | |
| SCHEMBL8198722 | 0.84 | LMNA (0.60) | LMNAADKP2RY6P2RY14NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060183-B1 | 5'-DEOXYCYTIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-1060183-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999040099-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-08-12 | — | — | WO | disclosed |