SCHEMBL7209817

SCHEMBL7209817

CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](n2cnc3c(N=O)ncnc32)C[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.39
P2RY1 P47900 2/20 0.38
POLB P06746 1/20 0.36
ENPP1 P22413 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25752681 0.88 HIF1A (0.37) HIF1AP2RY1POLBENPP1
SCHEMBL11986893 0.86 POLB (0.47) P2RY1POLBENPP1
SCHEMBL21317437 0.86 POLB (0.47) P2RY1POLBENPP1
SCHEMBL30197148 0.86 POLB (0.47) P2RY1POLBENPP1
SCHEMBL7215063 0.86 POLB (0.47) P2RY1POLBENPP1
SCHEMBL30944277 0.86 HIF1A (0.40) HIF1AP2RY1POLBENPP1
SCHEMBL1140779 0.86 HIF1A (0.42) HIF1AP2RY1POLBENPP1
SCHEMBL30944273 0.83 HIF1A (0.39) HIF1AP2RY1POLBENPP1
SCHEMBL22589997 0.82 P2RY1 (0.45) P2RY1
SCHEMBL2991340 0.82 TLR7 (0.38) HIF1AP2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6617106-B1 Methods for preparing oligonucleotides containing non-standard nucleotides BENNER, STEVEN 2003-09-09 US disclosed
US-6140496-A Precursors for deoxyribonucleotides containing non-standard nucleosides BENNER, STEVEN 2000-10-31 US disclosed