Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.42 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 3/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724669 | 0.95 | PFKFB3 (0.53) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6720563 | 0.93 | PFKFB3 (0.55) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6717907 | 0.93 | PFKFB3 (0.55) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6718694 | 0.92 | PFKFB3 (0.48) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6720387 | 0.90 | PFKFB3 (0.52) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6716553 | 0.89 | LMNA (0.53) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6714964 | 0.89 | SGK1 (0.49) | PFKFB3MAPK10LMNABRD4ITGA1 | |
| SCHEMBL6720455 | 0.88 | MAPK10 (0.46) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6720429 | 0.87 | LMNA (0.50) | PFKFB3MAPK10TP53LMNAMAPT | |
| SCHEMBL6714983 | 0.85 | CDK1 (0.50) | PFKFB3MAPK10TP53LMNAITGA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |