Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210537 | 1.00 | MAPT (0.32) | MAPTCRHBPCRHR2SMN1; SMN2HRH3 | |
| SCHEMBL7210500 | 0.84 | KDM4E (0.37) | MAPTCRHBPCRHR2SMN1; SMN2HRH3 | |
| SCHEMBL7210503 | 0.84 | KDM4E (0.37) | MAPTCRHBPCRHR2SMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL7210309 | 0.83 | KDM4E (0.39) | MAPTCRHBPCRHR2SMN1; SMN2HRH3 | |
| Hydrochloric Acid SCHEMBL7216184 | 0.83 | KDM4E (0.39) | MAPTCRHBPCRHR2SMN1; SMN2HRH3 | |
| SCHEMBL7215272 | 0.77 | PDE10A (0.39) | MAPTPDE10AKDM4EPDE1APDE1B | |
| SCHEMBL7215268 | 0.77 | PDE10A (0.39) | MAPTPDE10AKDM4EPDE1APDE1B | |
| SCHEMBL7211920 | 0.72 | PDE10A (0.38) | PDE10APDE1APDE1BPDE1C | |
| SCHEMBL7211918 | 0.72 | PDE10A (0.38) | PDE10APDE1APDE1BPDE1C | |
| SCHEMBL7779987 | 0.64 | MEN1 (0.33) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617336-B1 | Treatment of urinary incontinence, venous insufficiency, migraine or gastrointestinal disorders | SANOFI-SYNTHELABO (FR) | 2003-09-09 | — | — | US | disclosed |
| EP-1240146-A1 | 2-ARYLQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001038310-A1 | 2-ARYLQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2001-05-31 | — | — | WO | disclosed |