Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210503 | 1.00 | KDM4E (0.37) | KDM4EPDE10ACD274PDCD1PDK1 | |
| Hydrochloric Acid SCHEMBL7210309 | 0.99 | KDM4E (0.39) | KDM4EPDE10ACD274PDCD1PDK1 | |
| Hydrochloric Acid SCHEMBL7216184 | 0.99 | KDM4E (0.39) | KDM4EPDE10ACD274PDCD1PDK1 | |
| SCHEMBL7210539 | 0.84 | MAPT (0.32) | KDM4EPDE10ACD274PDK1PDK2 | |
| SCHEMBL7210537 | 0.84 | MAPT (0.32) | KDM4EPDE10ACD274PDK1PDK2 | |
| SCHEMBL7211975 | 0.74 | PDE10A (0.48) | KDM4EPDE10APDK1PDE1APDE1B | |
| SCHEMBL7211972 | 0.74 | PDE10A (0.48) | KDM4EPDE10APDK1PDE1APDE1B | |
| SCHEMBL5347104 | 0.69 | KDM4E (0.54) | KDM4ELMNAALDH1A1HRH3 | |
| SCHEMBL7210617 | 0.69 | PDE10A (0.43) | KDM4EPDE10APDK1PDE1APDE1B | |
| SCHEMBL8025972 | 0.69 | KDM4E (0.36) | KDM4EP2RX7L3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617336-B1 | Treatment of urinary incontinence, venous insufficiency, migraine or gastrointestinal disorders | SANOFI-SYNTHELABO (FR) | 2003-09-09 | — | — | US | disclosed |