Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210519 | 0.84 | PDE4A (0.33) | PDE4APDE4CPDE4D | |
| SCHEMBL7210224 | 0.83 | PDE4A (0.39) | PDE4APDE4CPDE4DMTNR1AMTNR1B | |
| SCHEMBL7588354 | 0.78 | MTNR1A (0.39) | PDE4APDE4CPDE4DMTNR1AMTNR1B | |
| SCHEMBL7210525 | 0.77 | PDE4A (0.32) | PDE4APDE4CPDE4D | |
| SCHEMBL7210273 | 0.74 | PDE4A (0.34) | PDE4APDE4CPDE4DMTNR1AMTNR1B | |
| SCHEMBL17430074 | 0.74 | MCHR1 (0.53) | PDE4APDE4CPDE4D | |
| SCHEMBL17430077 | 0.73 | PDE4A (0.41) | PDE4APDE4CPDE4DMTNR1AMTNR1B | |
| SCHEMBL7118786 | 0.73 | PARP1 (0.43) | — | |
| SCHEMBL7216226 | 0.72 | PDE4A (0.34) | PDE4APDE4CPDE4D | |
| SCHEMBL15237684 | 0.71 | MCHR1 (0.55) | PDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617336-B1 | Treatment of urinary incontinence, venous insufficiency, migraine or gastrointestinal disorders | SANOFI-SYNTHELABO (FR) | 2003-09-09 | — | — | US | disclosed |
| EP-1240146-A1 | 2-ARYLQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001038310-A1 | 2-ARYLQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2001-05-31 | — | — | WO | disclosed |