Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843055 | 0.88 | GRIN2B (0.58) | GRIN2BALDH1A1HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL10838416 | 0.88 | GRIN2B (0.55) | GRIN2BALDH1A1MAPTHSD17B10HTR1A | |
| SCHEMBL7564279 | 0.87 | GRIN2B (0.57) | GRIN2BALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL9825056 | 0.86 | GRIN2B (0.56) | GRIN2BALDH1A1HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9825181 | 0.85 | GRIN2B (0.55) | GRIN2BALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL9825127 | 0.82 | GRIN2B (0.66) | GRIN2BALDH1A1MAPTHTR1ADRD2 | |
| SCHEMBL6214174 | 0.81 | POLB (0.53) | EPHX2KMT2ATDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10682283 | 0.80 | GRIN2B (0.64) | GRIN2BALDH1A1MAPTHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL10682276 | 0.80 | GRIN2B (0.64) | GRIN2BALDH1A1MAPTHTR1ADRD2 | |
| SCHEMBL8302305 | 0.79 | GRIN2B (0.52) | GRIN2BALDH1A1MAPTHSD17B10HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |