Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 10/20 | 0.47 |
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440778 | 0.90 | GRIN2B (0.53) | GRIN2BHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL8439771 | 0.86 | GRIN2B (0.52) | GRIN2BHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL7564279 | 0.86 | GRIN2B (0.57) | GRIN2BHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL5843055 | 0.85 | GRIN2B (0.58) | GRIN2BHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL9825056 | 0.80 | GRIN2B (0.56) | GRIN2BHTR1ADRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9825181 | 0.79 | GRIN2B (0.55) | GRIN2BHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL7210683 | 0.79 | GRIN2B (0.55) | GRIN2BHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL8300540 | 0.78 | HTR1A (0.56) | HTR1ADRD2HTR2AACHEEPHX2 | |
| SCHEMBL8301786 | 0.77 | HTR1A (0.53) | GRIN2BHTR1ADRD2HTR2ASMYD3 | |
| SCHEMBL9825127 | 0.76 | GRIN2B (0.66) | GRIN2BHTR1ADRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848707-B1 | 4-(CYCLOALKYL)PIPERIDINES AND 4-(CYCLOALKYLALKYL)-PIPERIDINES DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATIONS THEREOF | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |