Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.78 |
| ▸ | KDR | P35968 | 12/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.77 |
| ▸ | FLT1 | P17948 | 7/20 | 0.77 |
| ▸ | FLT4 | P35916 | 6/20 | 0.77 |
| ▸ | SRC | P12931 | 5/20 | 0.72 |
| ▸ | RET | P07949 | 3/20 | 0.72 |
| ▸ | CIT | O14578 | 1/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.72 |
| ▸ | STK17B | O94768 | 1/20 | 0.72 |
| ▸ | STK10 | O94804 | 1/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209535 | 0.96 | KDR (0.77) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7214422 | 0.91 | EGFR (0.74) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5958913 | 0.88 | KDR (0.76) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7211073 | 0.88 | KDR (0.75) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5959060 | 0.88 | KDR (0.76) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6431449 | 0.87 | FLT1 (0.71) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL7209593 | 0.87 | KDR (0.73) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7857964 | 0.87 | KDR (1.00) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL7870593 | 0.86 | KDR (0.98) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5958890 | 0.86 | KDR (0.72) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | claimed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | claimed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |