Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.74 |
| ▸ | RET | P07949 | 4/20 | 0.73 |
| ▸ | KIF5B | P33176 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 12/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.73 |
| ▸ | FLT1 | P17948 | 6/20 | 0.73 |
| ▸ | FLT4 | P35916 | 4/20 | 0.73 |
| ▸ | SRC | P12931 | 9/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.66 |
| ▸ | STK17B | O94768 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211048 | 0.91 | EGFR (0.78) | EGFRRETKIF5BKDRFGFR1 | |
| SCHEMBL7209535 | 0.87 | KDR (0.77) | EGFRRETKIF5BKDRFGFR1 | |
| SCHEMBL6431249 | 0.87 | RET (0.60) | EGFRRETKIF5BKDRFGFR1 | |
| SCHEMBL11517 | 0.86 | KDR (0.84) | EGFRRETKIF5BKDRFGFR1 | |
| Hydrochloric Acid SCHEMBL6434957 | 0.85 | RET (0.58) | EGFRRETKIF5BKDRFGFR1 | |
| SCHEMBL7859435 | 0.85 | SRC (0.77) | EGFRRETKIF5BKDRFLT4 | |
| SCHEMBL7867160 | 0.85 | KDR (0.83) | EGFRRETKIF5BKDRFGFR1 | |
| SCHEMBL6097412 | 0.85 | KDR (0.58) | EGFRRETKIF5BKDRFGFR1 | |
| SCHEMBL16760462 | 0.85 | RET (1.00) | RETKIF5BKDRSRC | |
| Hydrochloric Acid SCHEMBL7866060 | 0.84 | KDR (0.84) | EGFRRETKIF5BKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | claimed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | claimed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |