Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211341 | 0.80 | SLC6A4 (0.56) | SLC6A4SLC6A3SLC6A2HTR2AKCNH2 | |
| SCHEMBL7065184 | 0.78 | SLC6A4 (0.48) | SLC6A4SLC6A3SLC6A2HTR2AKCNH2 | |
| SCHEMBL7065179 | 0.77 | SLC6A4 (0.57) | SLC6A4SLC6A2HTR2AKCNH2SCN9A | |
| SCHEMBL10153946 | 0.77 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL6946647 | 0.74 | SLC6A4 (0.76) | SLC6A4SLC6A3SLC6A2HTR2AKCNH2 | |
| SCHEMBL6151567 | 0.74 | SLC6A4 (0.70) | SLC6A4SLC6A3SLC6A2HTR2AKCNH2 | |
| SCHEMBL20558423 | 0.71 | ALDH1A1 (0.61) | SCN9AALDH1A1BRD4LMNASMN1; SMN2 | |
| SCHEMBL7211553 | 0.70 | SLC6A4 (0.71) | SLC6A4SLC6A3SLC6A2HTR2AKCNH2 | |
| SCHEMBL7061630 | 0.68 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2HTR2AKCNH2 | |
| SCHEMBL10650851 | 0.67 | PIK3CA (0.57) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610747-B2 | Such as 4-(2,3-dihydro-1-benzothien-5-yloxy)-3-((methylamino) methyl)-benzenesulfonamide for use as serotonin re-uptake inhibitors (SSRIs) in treatment of depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |