Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 17/20 | 0.52 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7206178 | 0.99 | CHEK1 (0.52) | CHEK1PDGFRBMAPK7AURKA | |
| SCHEMBL7205566 | 0.89 | CHEK1 (0.68) | CHEK1PDGFRB | |
| Hydrochloric Acid SCHEMBL7206387 | 0.89 | CHEK1 (0.67) | CHEK1PDGFRB | |
| SCHEMBL4518666 | 0.88 | PDGFRB (0.46) | CHEK1PDGFRBMAPK7 | |
| Hydrochloric Acid SCHEMBL7206364 | 0.87 | CHEK1 (0.46) | CHEK1PDGFRBMAPK7 | |
| SCHEMBL7209523 | 0.87 | KDR (0.49) | PDGFRBAURKA | |
| Hydrochloric Acid SCHEMBL7209557 | 0.86 | KDR (0.48) | PDGFRBAURKA | |
| SCHEMBL4506547 | 0.85 | PDGFRB (0.53) | CHEK1PDGFRBMAPK7 | |
| Hydrochloric Acid SCHEMBL7209559 | 0.85 | PDGFRB (0.53) | CHEK1PDGFRBMAPK7 | |
| SCHEMBL4519142 | 0.83 | CHEK1 (0.77) | CHEK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |