Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212241 | 0.88 | HRH3 (0.48) | HRH3MAOBMEN1KMT2AMAPT | |
| SCHEMBL5637830 | 0.86 | LSS (0.48) | HRH3MEN1KMT2A | |
| SCHEMBL5635676 | 0.86 | LSS (0.48) | HRH3MEN1KMT2A | |
| SCHEMBL5636080 | 0.85 | LSS (0.47) | HRH3MEN1KMT2A | |
| SCHEMBL5638059 | 0.78 | LSS (0.48) | MEN1KMT2A | |
| SCHEMBL7218423 | 0.78 | TSHR (0.55) | MAPTTP53 | |
| SCHEMBL5639304 | 0.72 | LSS (0.47) | HRH3MEN1KMT2AMAPTBCL2L1 | |
| SCHEMBL5639302 | 0.72 | LSS (0.47) | HRH3MEN1KMT2AMAPTBCL2L1 | |
| SCHEMBL5638718 | 0.71 | MEN1 (0.59) | HRH3MEN1KMT2AMAPTBCL2L1 | |
| SCHEMBL5638357 | 0.71 | LSS (0.48) | HRH3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |