Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212202 | 0.88 | HRH3 (0.47) | HRH3MAPTMAOBMEN1KMT2A | |
| SCHEMBL5637830 | 0.87 | LSS (0.48) | HRH3MEN1KMT2A | |
| SCHEMBL5635676 | 0.87 | LSS (0.48) | HRH3MEN1KMT2A | |
| SCHEMBL5636080 | 0.86 | LSS (0.47) | HRH3MEN1KMT2A | |
| SCHEMBL5638059 | 0.79 | LSS (0.48) | MEN1KMT2A | |
| SCHEMBL7213286 | 0.78 | MAPT (0.45) | HRH3MAPTMAOBTP53ALDH1A1 | |
| SCHEMBL5639195 | 0.78 | LSS (0.43) | HRH3MEN1KMT2A | |
| SCHEMBL7218398 | 0.75 | MAPT (0.46) | HRH3MAPTMEN1KMT2ATP53 | |
| SCHEMBL5638718 | 0.75 | MEN1 (0.59) | HRH3MAPTMEN1KMT2ATP53 | |
| SCHEMBL5639178 | 0.75 | LSS (0.46) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |