SCHEMBL7212277

SCHEMBL7212277

Brc1ccccc1Cn1cnc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 8/20 0.67
CYP11B2 P19099 8/20 0.67
TNF P01375 2/20 0.60
TDP1 Q9NUW8 1/20 0.58
SMN1; SMN2 Q16637 4/20 0.55
HTT P42858 4/20 0.55
MAPK1 P28482 2/20 0.55
MAPT P10636 2/20 0.55
NPC1 O15118 1/20 0.55
NFKB1 P19838 1/20 0.55
RAB9A P51151 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55
LMNA P02545 3/20 0.54
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
PKM P14618 1/20 0.51
BRD4 O60885 1/20 0.51
ALDH1A1 P00352 1/20 0.50
HDAC1 Q13547 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30826274 0.88 CYP11B1 (0.77) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL4142913 0.88 CYP11B1 (0.77) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL124313 0.86 CYP11B1 (0.67) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
Hydrochloric Acid SCHEMBL31253891 0.86 CYP11B1 (0.75) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
Bromide SCHEMBL31253900 0.86 CYP11B1 (0.75) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL20550865 0.81 CYP11B1 (0.69) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL28996363 0.80 CYP11B1 (0.67) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL8618130 0.80 CYP11B1 (0.67) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL7215799 0.80 CYP11B1 (0.67) CYP11B1CYP11B2TNFTDP1SMN1; SMN2
SCHEMBL30322779 0.80 CYP11B1 (0.67) CYP11B1CYP11B2TNFTDP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097618-B1 POST-TREATMENT FOR COPPER ON PRINTED CIRCUIT BOARDS FRYS METALS INC DBA ALPHA METALS INC (US) 2003-03-26 EP claimed
US-9865952-B2 Plug contact with organic coating and printed circuit board arrangement CONTINENTAL AUTOMOTIVE GMBH (DE) 2018-01-09 US disclosed
US-20170179628-A1 PLUG CONTACT WITH ORGANIC COATING AND PRINTED CIRCUIT BOARD ARRANGEMENT CONTINENTAL AUTOMOTIVE GMBH (DE) 2017-06-22 US disclosed
CN-104066730-A Heterocyclic compounds and their use as type III receptor tyrosine kinase modulators AMBIT BIOSCIENCES CORP 2014-09-24 CN disclosed