Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 7/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 7/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655297 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| SCHEMBL7212881 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7663482 | 0.98 | OPRM1 (0.97) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7663494 | 0.98 | OPRM1 (0.97) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7663489 | 0.98 | OPRM1 (0.97) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| SCHEMBL7207726 | 0.84 | OPRM1 (0.72) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7661204 | 0.84 | OPRM1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| SCHEMBL7661211 | 0.84 | OPRM1 (0.72) | OPRM1OPRD1OPRK1MRGPRX2SIGMAR1 | |
| SCHEMBL7207717 | 0.84 | OPRM1 (0.72) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7207722 | 0.84 | OPRM1 (0.72) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003502277-A | — | — | 2003-01-21 | — | — | JP | claimed |
| US-6498196-B1 | THIO-AMINOTETRALINS; ANALGESICS; OPIOID RECEPTOR AFFINITY; SIDE EFFECT REDUCTION | ASTRAZENECA CANADA INC. (CA) | 2002-12-24 | — | — | US | claimed |
| EP-1140815-A1 | NOVEL THIO-AMINOTETRALIN COMPOUNDS USEFUL IN PAIN MANAGEMENT | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037438-A1 | NOVEL THIO-AMINOTETRALIN COMPOUNDS USEFUL IN PAIN MANAGEMENT | ASTRAZENECA AB (SE) | 2000-06-29 | — | — | WO | claimed |
| US-6498196-B1 | THIO-AMINOTETRALINS; ANALGESICS; OPIOID RECEPTOR AFFINITY; SIDE EFFECT REDUCTION | ASTRAZENECA CANADA INC. (CA) | 2002-12-24 | — | — | US | disclosed |
| EP-1140815-A1 | NOVEL THIO-AMINOTETRALIN COMPOUNDS USEFUL IN PAIN MANAGEMENT | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037438-A1 | NOVEL THIO-AMINOTETRALIN COMPOUNDS USEFUL IN PAIN MANAGEMENT | ASTRAZENECA AB (SE) | 2000-06-29 | — | — | WO | disclosed |