⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094875 | 0.90 | — | — | |
| SCHEMBL9441397 | 0.90 | — | — | |
| SCHEMBL9441469 | 0.89 | — | — | |
| SCHEMBL9091989 | 0.84 | HTR2A (0.40) | — | |
| SCHEMBL9092778 | 0.76 | HTR7 (0.38) | — | |
| SCHEMBL7213168 | 0.72 | HTR2C (0.39) | — | |
| SCHEMBL9093453 | 0.71 | HTR2C (0.32) | — | |
| SCHEMBL9094860 | 0.68 | HTR2A (0.39) | — | |
| SCHEMBL9426278 | 0.67 | — | — | |
| SCHEMBL9091843 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624302-B2 | Culturing immunosuppressants, neurotrophic agents, and macrolactone antibiotics; side effect reduction | KOSAN BIOSCIENCES, INC. | 2003-09-23 | — | — | US | disclosed |
| US-20030144315-A1 | Novel polyketide derivatives | CHU DANIEL (US) | 2003-07-31 | — | — | US | disclosed |
| US-6569867-B2 | As drugs | KOSAN BIOSCIENCES, INC. | 2003-05-27 | — | — | US | disclosed |
| EP-1282626-A2 | POLYKETIDE DERIVATIVES | Kosan Biosciences, Inc. (US) | 2003-02-12 | — | — | EP | disclosed |
| US-20020183348-A1 | For use as drugs | CHU DANIEL (US) | 2002-12-05 | — | — | US | disclosed |
| US-20020065295-A1 | Novel polyketide derivatives | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-05-30 | — | — | US | disclosed |
| WO-2001087884-A2 | POLYKETIDE DERIVATIVES | KOSAN BIOSCIENCES, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
| EP-0532088-B1 | O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl macrolides | MERCK & CO INC (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5352783-A | Treating autoimmune diseases | MERCK & CO., INC. (US) | 1994-10-04 | — | — | US | disclosed |
| US-5349061-A | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| US-5310901-A | Autoimmune diseases; antiinflammatory agents; fungicides; prevention of organ transplant rejection; alkylation and/or arylation at C-42 | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5252732-A | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1993-10-12 | — | — | US | disclosed |
| WO-1993005058-A1 | O-HETEROARYL, O-ALKYLHETEROARYL, O-ALKENYLHETEROARYL AND O-ALKYNYLHETEROARYLMACROLIDES | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0532088-A1 | O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl macrolides | MERCK & CO. INC. (US) | 1993-03-17 | — | — | EP | disclosed |