Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.60 |
| ▸ | STS | P08842 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.56 |
| ▸ | SHBG | P04278 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SNCA | P37840 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219423 | 0.89 | STS (0.58) | ESR1STSHSD17B10HSD17B1LMNA | |
| SCHEMBL7646038 | 0.86 | STS (0.72) | ESR1ESR2STSCYP2C9 | |
| SCHEMBL7646041 | 0.86 | STS (0.72) | ESR1ESR2STSCYP2C9 | |
| SCHEMBL5707489 | 0.86 | ESR1 (0.73) | ESR1ESR2STSHSD17B10HSD17B1 | |
| SCHEMBL7218327 | 0.85 | ESR1 (0.71) | ESR1ESR2STSHSD17B10HSD17B1 | |
| SCHEMBL5159033 | 0.85 | ESR1 (0.71) | ESR1ESR2STSHSD17B10HSD17B1 | |
| SCHEMBL7949541 | 0.85 | ESR1 (0.77) | ESR1ESR2STSHSD17B10HSD17B1 | |
| SCHEMBL5707483 | 0.83 | ESR1 (0.69) | ESR1ESR2STSHSD17B10HSD17B1 | |
| SCHEMBL7102035 | 0.82 | ESR1 (0.67) | ESR1ESR2STSHSD17B10HSD17B1 | |
| SCHEMBL23759191 | 0.81 | STS (0.76) | ESR1ESR2STSHSD17B10HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638923-B2 | Has inhibitory activity against steroid sulfatase and are useful in treating or preventing hormone dependent diseases | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-10-28 | — | — | US | disclosed |
| US-20020058651-A1 | Estra-1,3,5(10), 16-tetraene derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2002-05-16 | — | — | US | disclosed |
| US-6262043-B1 | SHOW INHIBITORY ACTIVITY AGAINST STEROID SULFATASE AND ARE USEFUL IN TREATING OR PREVENTING HORMONE DEPENDENT DISEASES. | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058651-A1 | Estra-1,3,5(10), 16-tetraene derivatives | HSD17B11, NR5A1, CYP19A1 | ESR1 7/4885ESR2 5/4885STS 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.