Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.64 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.59 |
| ▸ | STS | P08842 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | SHBG | P04278 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219080 | 0.90 | ESR1 (0.63) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL5159033 | 0.88 | ESR1 (0.71) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL7218327 | 0.88 | ESR1 (0.71) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL7213165 | 0.85 | ESR1 (0.65) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL9362072 | 0.85 | ESR1 (0.59) | ESR1ESR2STSAKR1C3CYP17A1 | |
| SCHEMBL5707489 | 0.85 | ESR1 (0.73) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL23759191 | 0.83 | STS (0.76) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL5707604 | 0.83 | ESR1 (0.74) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL7218332 | 0.82 | ESR1 (0.70) | ESR1ESR2HSD17B1STSLMNA | |
| SCHEMBL5707483 | 0.82 | ESR1 (0.69) | ESR1ESR2HSD17B1STSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262043-B1 | SHOW INHIBITORY ACTIVITY AGAINST STEROID SULFATASE AND ARE USEFUL IN TREATING OR PREVENTING HORMONE DEPENDENT DISEASES. | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-07-17 | — | — | US | disclosed |