⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268630 | 1.00 | — | — | |
| SCHEMBL9266399 | 1.00 | — | — | |
| SCHEMBL9266033 | 1.00 | — | — | |
| SCHEMBL9271781 | 1.00 | — | — | |
| SCHEMBL9267156 | 0.87 | PLA2G2A (0.78) | — | |
| SCHEMBL9263596 | 0.87 | PLA2G2A (0.78) | — | |
| SCHEMBL9264175 | 0.87 | PLA2G2A (0.78) | — | |
| SCHEMBL9268834 | 0.85 | — | — | |
| SCHEMBL9270260 | 0.84 | PLA2G2A (0.74) | — | |
| SCHEMBL17022587 | 0.84 | OXER1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995013266-A1 | ACYLPYRROLE-ALKANOIC ACIDS AND INDOLE-2-ALKANOIC ACIDS PLUS THEIR DERIVATIVES FOR USE AS INHIBITORS OF PHOSPHOLIPASE A¿2? | MERCKLE GMBH CHEM.-PHARM. FABRIK (DE) | 1995-05-18 | — | — | WO | claimed |
| EP-0923546-B1 | ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2 | MERCKLE GMBH (DE) | 2003-11-26 | — | — | EP | disclosed |
| US-6310217-B1 | ANTIINFLAMMATORY AND ANALGESIC AGENTS | MERCKLE GMBH (DE) | 2001-10-30 | — | — | US | disclosed |
| EP-0923546-A1 | ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2 | Merckle GmbH (DE) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998005637-A1 | ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A¿2? | MERCKLE GMBH (DE) | 1998-02-12 | — | — | WO | disclosed |
| WO-1995013266-A1 | ACYLPYRROLE-ALKANOIC ACIDS AND INDOLE-2-ALKANOIC ACIDS PLUS THEIR DERIVATIVES FOR USE AS INHIBITORS OF PHOSPHOLIPASE A¿2? | MERCKLE GMBH CHEM.-PHARM. FABRIK (DE) | 1995-05-18 | — | — | WO | disclosed |