Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664962 | 0.73 | — | — | |
| SCHEMBL5530224 | 0.72 | MAPT (0.42) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1447816 | 0.67 | MAPT (0.45) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3807641 | 0.67 | MAPT (0.39) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27695943 | 0.67 | — | — | |
| SCHEMBL27721648 | 0.63 | — | — | |
| SCHEMBL235799 | 0.63 | MAPT (0.41) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28222341 | 0.61 | MAPT (0.44) | MAPTTDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27856872 | 0.61 | NISCH (0.34) | — | |
| SCHEMBL4153725 | 0.60 | MAPT (0.61) | MAPTTDP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296699-A | Pyrazolo [1, 5-a ] pyrimidine compounds | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-10-29 | — | — | CN | claimed |
| CN-1073089-C | Benzodiazepine derivatives, compositions thereof and their use in the manufacture of medicaments | SHIONOGI & CO (JP) | 2001-10-17 | — | — | CN | claimed |
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO., (US) | 2001-10-04 | — | — | US | claimed |
| CN-103570693-B | As the endocyclic compound of hepatitis c inhibitor and the application in medicine thereof | SUNSHINE LAKE PHARMA CO.,LTD. (CN) | 2015-10-14 | — | — | CN | disclosed |
| CN-102863428-B | Spiro-compounds taken as hepatitis c virus (HCV) inhibitor | GUANGDONG HEC PHARMACEUTICAL | 2014-12-24 | — | — | CN | disclosed |
| CN-103570693-A | Bridged compound serving as hepatitis C inhibitor and application of bridged compound in medicines | GUANGDONG HEC PHARMACEUTICAL | 2014-02-12 | — | — | CN | disclosed |
| CN-102863428-A | Spiro-compounds taken as hepatitis c virus (HCV) inhibitor | GUANGDONG HEC PHARMACEUTICAL | 2013-01-09 | — | — | CN | disclosed |
| CN-101506221-B | Estratriene derivatives and their use as 17 beta-hydroxysteroid dehydrogenase inhibitors | SOLVAY PHARM BV | 2012-09-12 | — | — | CN | disclosed |
| CN-101374843-B | Triazolopyridazines as tyrosine kinase modulators | JANSSEN PHARMACEUTICA NV | 2012-09-05 | — | — | CN | disclosed |
| CN-101641117-B | Pharmaceutical composition | KYOWA HAKKO KIRIN CO LTD | 2012-06-13 | — | — | CN | disclosed |
| CN-102414205-A | Isoxazole-pyrazole derivatives | HOFFMANN LA ROCHE | 2012-04-11 | — | — | CN | disclosed |
| CN-1777590-A | Indazole derivatives | KYOWA HAKKO KOGYO KK (JP) | 2006-05-24 | — | — | CN | disclosed |
| CN-1731994-A | Prophylactic and therapeutic agent for neuropathy | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-02-08 | — | — | CN | disclosed |
| CN-1170827-C | Benzofurylpyrone derivatives | ������������ʽ���� | 2004-10-13 | — | — | CN | disclosed |
| US-6613880-B2 | Autoimmune diseases; inflammatory conditions; competitive binding with Human Leukocyte Antigen displacing disease-inducing endogenous peptides | PHARMACIA CORPORATION | 2003-09-02 | — | — | US | disclosed |
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO., (US) | 2001-10-04 | — | — | US | disclosed |
| CN-1299359-A | Benzofurylpyrone derivatives | TEIJIN LTD (JP) | 2001-06-13 | — | — | CN | disclosed |
| CN-1156440-A | Method for producing acyloins | BASF AG (DE) | 1997-08-06 | — | — | CN | disclosed |
| WO-1996040753-A1 | PIPECOLIC ACID DERIVATIVES OF PROLINE THREONINE AMIDES USEFUL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | disclosed |
| CN-1064683-A | New beta-amino-alpha-hydroxycarboxylic acids and uses thereof | SANKYO CO (JP) | 1992-09-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | ARGLU1, PRR12, PTMS | MAPT 4124/4885TDP1 1172/4885SMN1; SMN2 4441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.