Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 11/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216586 | 0.82 | TAAR1 (0.54) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL4674867 | 0.82 | TAAR1 (0.54) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL7955916 | 0.80 | DPP4 (0.47) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL3131950 | 0.80 | DPP4 (0.47) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL5225287 | 0.80 | DPP4 (0.47) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL17045268 | 0.79 | TAAR1 (0.50) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL3674139 | 0.79 | TAAR1 (0.54) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL13995122 | 0.77 | AOC3 (0.44) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL1467599 | 0.77 | TAAR1 (0.52) | TAAR1IDO1DPP4DPP7CYP3A4 | |
| SCHEMBL7211801 | 0.76 | TAAR1 (0.45) | TAAR1DPP4DPP7CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |