Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 4/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.38 |
| ▸ | FAP | Q12884 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23420598 | 0.86 | HTR2A (0.50) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL4708624 | 0.82 | TAAR1 (0.52) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL7211808 | 0.82 | TAAR1 (0.52) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL5324683 | 0.80 | TAAR1 (0.45) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL3935731 | 0.80 | DPP4 (0.47) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL7997555 | 0.80 | DPP4 (0.47) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL3129897 | 0.78 | TAAR1 (0.44) | TAAR1DPP4DPP7DPP8DPP9 | |
| SCHEMBL19143458 | 0.78 | DPP4 (0.49) | TAAR1DPP4DPP7DPP8DPP9 | |
| Ortetamine SCHEMBL209899 | 0.77 | TAAR1 (0.52) | TAAR1HTR2ASLC6A2SLC6A4SLC6A3 | |
| Ortetamine SCHEMBL42180 | 0.77 | TAAR1 (0.52) | TAAR1HTR2ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |