Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.46 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.46 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 7/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726778 | 0.88 | AURKB (0.44) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL10268949 | 0.84 | AURKB (0.46) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL721974 | 0.84 | MAP3K7 (0.44) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL723557 | 0.83 | GRM4 (0.48) | AURKBAURKAINCENPTPX2 | |
| SCHEMBL10267292 | 0.82 | FYN (0.48) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL723490 | 0.82 | IRAK1 (0.38) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL725386 | 0.82 | PFKFB3 (0.39) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL12503592 | 0.82 | MAP3K7 (0.49) | AURKBMAP3K7TAB1IRAK4FYN | |
| SCHEMBL724763 | 0.81 | IRAK1 (0.41) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL724751 | 0.80 | MAP3K7 (0.47) | AURKBAURKAINCENPTPX2MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |