Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.44 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721430 | 0.88 | AURKB (0.46) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL10268949 | 0.87 | AURKB (0.46) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL723447 | 0.86 | FYN (0.38) | MAP3K7TAB1MTOR | |
| SCHEMBL722236 | 0.83 | AURKB (0.38) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL10267304 | 0.83 | MAP4K4 (0.43) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL725506 | 0.83 | KCNH2 (0.43) | AURKBAURKAINCENPTPX2MET | |
| SCHEMBL15209645 | 0.82 | CCNC (0.39) | AURKBAURKAINCENPTPX2MET | |
| SCHEMBL723385 | 0.81 | MTOR (0.43) | AURKBMAP3K7TAB1METKDR | |
| SCHEMBL723758 | 0.81 | DYRK1A (0.47) | AURKBAURKAINCENPTPX2MAP3K7 | |
| SCHEMBL724280 | 0.81 | AURKB (0.38) | AURKBAURKAINCENPTPX2MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |