Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435827 | 0.91 | SLC1A1 (0.49) | CNR2MEN1KMT2AIDO1CES2 | |
| SCHEMBL30849676 | 0.84 | CNR2 (0.49) | CNR2MEN1KMT2AIDO1TDO2 | |
| SCHEMBL23021624 | 0.83 | SLC6A2 (0.53) | CNR2PPARGPPARAMEN1KMT2A | |
| SCHEMBL7152593 | 0.82 | ADRB2 (0.65) | SLC6A2SLC6A4 | |
| SCHEMBL7152595 | 0.82 | ADRB2 (0.65) | SLC6A2SLC6A4 | |
| SCHEMBL27731739 | 0.80 | SLC16A3 (0.60) | CNR2MEN1KMT2A | |
| SCHEMBL2291798 | 0.80 | SLC16A3 (0.60) | CNR2MEN1KMT2A | |
| SCHEMBL2298340 | 0.80 | SLC16A3 (0.60) | CNR2MEN1KMT2A | |
| SCHEMBL22785928 | 0.80 | CA1 (0.47) | CNR2IDO1TDO2GRIN2B | |
| SCHEMBL28496558 | 0.80 | CNR2 (0.48) | CNR2PPARGPPARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | disclosed |
| CN-1131865-C | Substituted imidazo [1,2a ] azines as selective COX-2 inhibitors | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-24 | — | — | CN | disclosed |
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | disclosed |
| CN-1321157-A | Substd. imidazo [1,2] azines as selective inhibitors of COX-2 | S A L V A T LAB SA (ES) | 2001-11-07 | — | — | CN | disclosed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | disclosed |