Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 10/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214550 | 1.00 | RECQL (0.46) | RECQLLOXLOXL3LOXL2ALDH1A1 | |
| SCHEMBL16332626 | 0.77 | RECQL (0.53) | RECQLLOXLOXL3LOXL2ALDH1A1 | |
| SCHEMBL1886874 | 0.75 | RECQL (0.58) | RECQLLOXLOXL3LOXL2ALDH1A1 | |
| SCHEMBL2438076 | 0.75 | HTT (0.61) | RECQLALDH1A1GAAKDM4EMAPT | |
| SCHEMBL38657127 | 0.75 | HTT (0.61) | RECQLALDH1A1GAAKDM4EMAPT | |
| SCHEMBL17320231 | 0.75 | HTT (0.61) | RECQLALDH1A1GAAKDM4EMAPT | |
| SCHEMBL2438072 | 0.75 | HTT (0.61) | RECQLALDH1A1GAAKDM4EMAPT | |
| SCHEMBL2371002 | 0.73 | GABRP (0.62) | RECQLLOXLOXL3LOXL2ALDH1A1 | |
| SCHEMBL29421806 | 0.73 | GABRP (0.62) | RECQLLOXLOXL3LOXL2ALDH1A1 | |
| SCHEMBL8136095 | 0.72 | RECQL (0.55) | RECQLALDH1A1GAAMAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509361-B1 | Inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the preparation of the contemplated compounds and for the use of a contemplated compound in treating a mammalian host having a p38 kinase or | PHARMACIA CORPORATION | 2003-01-21 | — | — | US | disclosed |