Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 11/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.44 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390727 | 0.78 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL1865702 | 0.76 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL11232802 | 0.73 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL9747422 | 0.71 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL16946121 | 0.71 | CYP19A1 (0.63) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL28750656 | 0.70 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL10518956 | 0.69 | CYP11B1 (0.70) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL11082155 | 0.69 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1CYP1A2POLB | |
| SCHEMBL19541843 | 0.69 | CYP19A1 (0.57) | CYP11B1CYP11B2CYP19A1POLB | |
| SCHEMBL6299116 | 0.69 | CYP11B1 (0.59) | CYP11B1CYP11B2CYP19A1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |