Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.69 |
| ▸ | MAOB | P27338 | 9/20 | 0.64 |
| ▸ | MAOA | P21397 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA3 | P07451 | 1/20 | 0.64 |
| ▸ | CA4 | P22748 | 1/20 | 0.64 |
| ▸ | CA6 | P23280 | 1/20 | 0.64 |
| ▸ | CA7 | P43166 | 1/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29828846 | 1.00 | MRGPRX4 (0.69) | MRGPRX4MAOBMAOANPC1MEN1 | |
| SCHEMBL5988383 | 0.87 | MRGPRX4 (0.69) | MRGPRX4MAOBMAOANPC1MEN1 | |
| SCHEMBL4823774 | 0.84 | MRGPRX4 (0.65) | MRGPRX4MAOBMAOANPC1MEN1 | |
| SCHEMBL22480680 | 0.82 | MRGPRX4 (1.00) | MRGPRX4FFAR1PPARDRAB9A | |
| SCHEMBL29966607 | 0.79 | MAOB (0.80) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL29092205 | 0.79 | MAOB (0.80) | MAOBMAOACA12CA1CA2 | |
| 7-Benzyloxycoumarin SCHEMBL3901170 | 0.78 | MAOB (1.00) | MAOBMAOANPC1MEN1CA12 | |
| SCHEMBL7315339 | 0.78 | MAOB (0.69) | MAOBMAOANPC1MEN1CA12 | |
| SCHEMBL28151748 | 0.78 | MAOB (0.65) | MAOBMAOANPC1MEN1CA12 | |
| 7-Benzyloxycoumarin SCHEMBL29365449 | 0.78 | MAOB (1.00) | MAOBMAOANPC1MEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
| CN-116981672-A | Macrocyclic compounds as CFTR modulators | 爱杜西亚药品有限公司 | 2023-10-31 | — | — | CN | disclosed |
| WO-2022194399-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-09-22 | — | — | WO | disclosed |
| US-6610687-B1 | Phosphodiesterase IV inhibitors; treating or preventing inflammation | BAYER AKTIENGESELLSCHAFT (DE) | 2003-08-26 | — | — | US | disclosed |
| EP-1187821-A1 | BENZOFURANYLSULFONATES | Bayer Aktiengesellschaft (DE) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000069842-A1 | BENZOFURANYLSULFONATES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | MRGPRX4 201/4885MAOB 3987/4885MAOA 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.