Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | CASP1 | P29466 | 8/20 | 0.51 |
| ▸ | CASP7 | P55210 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.51 |
| ▸ | USP2 | O75604 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212196 | 0.87 | MERTK (0.51) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5451875 | 0.86 | ADORA1 (0.57) | PTGS2ALDH1A1CASP1CASP7CYP1A2 | |
| SCHEMBL7210164 | 0.86 | PTGS2 (0.49) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5448826 | 0.85 | ADORA1 (0.53) | PTGS2ALDH1A1CASP1CASP7CYP1A2 | |
| SCHEMBL7211775 | 0.85 | PTGS2 (0.48) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7210496 | 0.85 | MAPK14 (0.47) | PTGS2ALDH1A1CASP1CASP7CYP1A2 | |
| SCHEMBL7210216 | 0.84 | PTGS2 (0.48) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7216156 | 0.84 | PTGS2 (0.59) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL7210504 | 0.84 | PTGS2 (0.47) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7215223 | 0.84 | PTGS2 (0.71) | PTGS2ALDH1A1HSD17B10TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610698-B2 | Treatment of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and interleukin-8 mediated diseases | AMGEN, INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6410729-B1 | ANALGESICS; ANTIDIABETIC AGENTS; ANTIINFLAMMATORY AGENTS | AMGEN INC. | 2002-06-25 | — | — | US | disclosed |
| CN-1246858-A | Substituted pyrimidine compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |