Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.62 |
| ▸ | ITGA2B | P08514 | 17/20 | 0.62 |
| ▸ | ITGAV | P06756 | 8/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7217453 | 1.00 | ITGB3 (0.62) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| Trifluoroacetic Acid SCHEMBL7222095 | 0.99 | ITGB3 (0.62) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| Trifluoroacetic Acid SCHEMBL7216309 | 0.99 | ITGB3 (0.62) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| Trifluoroacetic Acid SCHEMBL7223027 | 0.97 | ITGB3 (0.61) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| Trifluoroacetic Acid SCHEMBL7222308 | 0.97 | ITGB3 (0.61) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL7215517 | 0.91 | ITGB3 (0.54) | ITGB3ITGA2BITGAVITGB5 | |
| SCHEMBL7217458 | 0.91 | ITGB3 (0.54) | ITGB3ITGA2BITGAVITGB5 | |
| SCHEMBL7222100 | 0.90 | ITGB3 (0.53) | ITGB3ITGA2BITGAVITGB5 | |
| SCHEMBL7217994 | 0.90 | ITGB3 (0.53) | ITGB3ITGA2BITGAVITGB5 | |
| Trifluoroacetic Acid SCHEMBL7221135 | 0.89 | ITGB3 (0.64) | ITGB3ITGA2BITGAVITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | claimed |
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | disclosed |
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |