Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.56 |
| ▸ | MMP9 | P14780 | 6/20 | 0.56 |
| ▸ | MMP8 | P22894 | 6/20 | 0.56 |
| ▸ | MMP1 | P03956 | 5/20 | 0.56 |
| ▸ | MMP3 | P08254 | 5/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075141 | 0.78 | MMP2 (0.80) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL27517321 | 0.76 | MMP2 (0.81) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7077478 | 0.75 | MMP2 (0.71) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7077872 | 0.75 | RXFP1 (0.52) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7080612 | 0.74 | MMP2 (0.54) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7075406 | 0.74 | MMP2 (0.77) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7078224 | 0.74 | MMP2 (0.77) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7077667 | 0.73 | MMP2 (0.57) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7075239 | 0.72 | MMP2 (0.60) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7075232 | 0.72 | MMP2 (0.60) | MMP2MMP9MMP8MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |
| US-6118001-A | ANTICANCER AGENT; ANTIARTHRITIC AGENT | DARWIN DISCOVERY, LTD. (GB) | 2000-09-12 | — | — | US | disclosed |