Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.75 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115364 | 0.93 | EGFR (0.88) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL7214801 | 0.91 | EGFR (0.85) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL7216160 | 0.89 | EGFR (0.78) | EGFRERBB2ERBB4 | |
| SCHEMBL7214671 | 0.86 | EGFR (0.82) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL30115316 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL7216113 | 0.86 | EGFR (0.81) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL7220355 | 0.85 | EGFR (0.84) | EGFRERBB2ERBB4 | |
| SCHEMBL7220947 | 0.84 | EGFR (0.83) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL7220501 | 0.84 | EGFR (0.71) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL30115314 | 0.83 | EGFR (1.00) | EGFRERBB2ERBB4ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |