Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | OXTR | P30559 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | LMNA | P02545 | 7/20 | 0.66 |
| ▸ | HTT | P42858 | 7/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GALR3 | O60755 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.55 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15452471 | 0.90 | EGFR (0.81) | EGFRKDM4EMAPK1MAPTOXTR | |
| SCHEMBL23682881 | 0.85 | KMT2A (1.00) | EGFRKDM4EMAPK1MAPTOXTR | |
| SCHEMBL15452736 | 0.83 | MAPK1 (0.75) | EGFRKDM4EMAPK1MAPTOXTR | |
| SCHEMBL10083177 | 0.79 | EGFR (0.65) | EGFRKDM4EMAPK1MAPTOXTR | |
| SCHEMBL7215763 | 0.78 | EGFR (0.97) | EGFRKDM4EMAPK1MAPTOXTR | |
| Hydrochloric Acid SCHEMBL7215860 | 0.77 | EGFR (1.00) | EGFRKDM4EMAPK1MAPTOXTR | |
| SCHEMBL168409 | 0.77 | EGFR (0.68) | EGFRMAPK1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4008118 | 0.73 | EGFR (0.57) | EGFRKDM4EMAPK1MAPTOXTR | |
| SCHEMBL14780086 | 0.72 | CSF1R (0.70) | EGFRMAPK1MEN1KMT2AGAA | |
| SCHEMBL15612915 | 0.72 | LMNA (0.57) | EGFRMAPK1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006055-A1 | SMALL MOLECULE BROAD-SPECTRUM ANTIBIOTICS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2024-01-04 | — | — | WO | disclosed |
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |