Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 1.00 |
| ▸ | FBP1 | P09467 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418279 | 0.81 | EGFR (0.77) | EGFRFBP1 | |
| SCHEMBL7222247 | 0.81 | EGFR (1.00) | EGFRFBP1ERBB2 | |
| SCHEMBL17940088 | 0.81 | EGFR (1.00) | EGFRFBP1ERBB2 | |
| SCHEMBL2995375 | 0.79 | EGFR (0.92) | EGFRFBP1 | |
| SCHEMBL6837371 | 0.79 | EGFR (1.00) | EGFR | |
| SCHEMBL12012727 | 0.79 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL1418145 | 0.78 | FBP1 (0.79) | EGFRFBP1ERBB2 | |
| SCHEMBL31060143 | 0.78 | EGFR (1.00) | EGFRFBP1 | |
| SCHEMBL1417946 | 0.77 | FBP1 (0.78) | EGFRFBP1 | |
| SCHEMBL8315497 | 0.76 | EGFR (0.79) | EGFRFBP1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| US-5679683-A | USEFUL FOR TREATING CANCER, ARTHRITIS, PSORIASIS, VASCULAR RESTENOSIS AND ANGIOGENESIS | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |