Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 20/20 | 0.84 |
| ▸ | ERBB4 | Q15303 | 19/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220753 | 0.97 | EGFR (0.84) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7220739 | 0.96 | EGFR (0.83) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7213879 | 0.90 | EGFR (0.84) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL29409571 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL238877 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7220498 | 0.86 | EGFR (0.79) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7220082 | 0.86 | EGFR (0.78) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7220678 | 0.83 | EGFR (0.75) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7214823 | 0.83 | EGFR (0.68) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7221044 | 0.83 | EGFR (0.91) | EGFRERBB2ERBB4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |