Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | CASP3 | P42574 | 2/20 | 0.74 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15452556 | 0.85 | KDM4E (1.00) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL15452470 | 0.85 | MEN1 (0.98) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL15426110 | 0.82 | NPC1 (0.77) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL15427152 | 0.77 | KDM4E (0.98) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL13771841 | 0.75 | NPC1 (0.64) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL15452557 | 0.75 | NPC1 (1.00) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2992623 | 0.74 | EGFR (1.00) | EGFRABCG2 | |
| SCHEMBL12255950 | 0.74 | ALDH1A1 (0.59) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14067425 | 0.74 | HPGD (0.68) | EGFRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5569425 | 0.74 | EGFR (0.72) | EGFRMAPK1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |