Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216580 | 1.00 | USP30 (0.53) | USP30L3MBTL1NPEPPSATMS1PR1 | |
| SCHEMBL7216590 | 1.00 | USP30 (0.53) | USP30L3MBTL1NPEPPSATMS1PR1 | |
| SCHEMBL463264 | 0.88 | USP30 (0.51) | USP30L3MBTL1ATMALDH1A1KDM4E | |
| SCHEMBL463263 | 0.88 | USP30 (0.51) | USP30L3MBTL1ATMALDH1A1KDM4E | |
| SCHEMBL3449300 | 0.83 | RORC (0.55) | USP30L3MBTL1ATMALDH1A1CHRM2 | |
| SCHEMBL7887604 | 0.83 | RORC (0.55) | USP30L3MBTL1ATMALDH1A1CHRM2 | |
| SCHEMBL5839366 | 0.83 | RORC (0.55) | USP30L3MBTL1ATMALDH1A1CHRM2 | |
| SCHEMBL14037432 | 0.83 | USP30 (0.62) | USP30L3MBTL1ATMS1PR1ALDH1A1 | |
| SCHEMBL13177349 | 0.83 | USP30 (0.62) | USP30L3MBTL1ATMS1PR1ALDH1A1 | |
| SCHEMBL853540 | 0.83 | USP30 (0.62) | USP30L3MBTL1ATMS1PR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |