Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.40 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289188 | 0.84 | LMNA (0.50) | CYP19A1MAPK1NPSR1SCD5PIK3CD | |
| SCHEMBL6289186 | 0.84 | LMNA (0.50) | CYP19A1MAPK1NPSR1SCD5PIK3CD | |
| SCHEMBL6292691 | 0.79 | PIK3CD (0.43) | MAPK1PIK3CDEDNRBEDNRAADORA1 | |
| SCHEMBL6289617 | 0.78 | CYP1A2 (0.50) | CYP19A1MAPK1NPSR1SCD5EDNRB | |
| SCHEMBL6293272 | 0.77 | EDNRB (0.40) | CYP19A1MAPK1NPSR1SCD5EDNRB | |
| SCHEMBL6292787 | 0.73 | EDNRA (0.44) | CYP19A1MAPK1NPSR1SCD5EDNRB | |
| SCHEMBL6288968 | 0.69 | MAPT (0.47) | PIK3CDADORA1MAPTALDH1A1 | |
| SCHEMBL6289705 | 0.68 | CYP19A1 (0.49) | CYP19A1MAPK1NPSR1SCD5EDNRB | |
| SCHEMBL6289722 | 0.68 | HTR2A (0.38) | NPSR1PIK3CDEDNRBEDNRAADORA1 | |
| SCHEMBL6292820 | 0.67 | MAPT (0.57) | PIK3CDEDNRAADORA1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573270-B1 | Endothelin receptor antagonists | PFIZER INC. | 2003-06-03 | — | — | US | disclosed |