Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.76 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ximelagatran SCHEMBL19065093 | 0.86 | F2 (1.00) | F2PLATPRSS1F10ALDH1A1 | |
| Ximelagatran SCHEMBL14509860 | 0.86 | F2 (1.00) | F2PLATPRSS1F10ALDH1A1 | |
| Ximelagatran SCHEMBL15908919 | 0.86 | F2 (1.00) | F2PLATPRSS1F10ALDH1A1 | |
| Ximelagatran SCHEMBL4845 | 0.86 | F2 (1.00) | F2PLATPRSS1F10ALDH1A1 | |
| SCHEMBL6818264 | 0.86 | F2 (0.77) | F2PLATPRSS1F10ALDH1A1 | |
| Ximelagatran SCHEMBL14542684 | 0.85 | F2 (0.76) | F2PLATPRSS1F10ALDH1A1 | |
| Ximelagatran SCHEMBL8039753 | 0.85 | F2 (0.76) | F2PLATPRSS1F10ALDH1A1 | |
| SCHEMBL8083322 | 0.85 | F2 (0.78) | F2PLATPRSS1F10ALDH1A1 | |
| Ximelagatran SCHEMBL7222774 | 0.81 | F2 (0.88) | F2PLATPRSS1F10ALDH1A1 | |
| SCHEMBL16502325 | 0.80 | F2 (0.63) | F2PLATPRSS1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518434-B2 | N-carboxyanhydrides (NCAs) are copupled directly to cyclic amino acids amide derivatives to form peptide linkage | ASTRAZENECA AB (SE) | 2003-02-11 | — | — | US | disclosed |
| US-20020128452-A1 | N-carboxyanhydrides (NCAs) are copupled directly to cyclic amino acids amide derivatives to form peptide linkage | ASTRAZENECA AB (SE) | 2002-09-12 | — | — | US | disclosed |