Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64373 | 0.74 | — | — | |
| Ammonia Solution, Strong SCHEMBL27855657 | 0.72 | — | — | |
| SCHEMBL4017380 | 0.68 | GAA (0.45) | DYRK1AHSD17B10NPC1MAPTRAB9A | |
| SCHEMBL356543 | 0.67 | — | — | |
| SCHEMBL31080198 | 0.59 | DYRK1A (0.40) | DYRK1AHSD17B10NPC1MAPTRAB9A | |
| SCHEMBL3454155 | 0.58 | ALDH1A1 (0.41) | DYRK1AHSD17B10MAPTGFERGAA | |
| SCHEMBL19732648 | 0.58 | — | — | |
| SCHEMBL286531 | 0.58 | MAPK1 (0.65) | NPC1MAPTRAB9AGAA | |
| SCHEMBL23500805 | 0.57 | — | — | |
| SCHEMBL1488113 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339702-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2001068619-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEX INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |