Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefuroxime Axetil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | PGR | P06401 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.50 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefuroxime Axetil SCHEMBL6859269 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL41099 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL7767287 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL379336 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL13575811 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL10556419 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL2221553 | 0.97 | ABCC4 (0.95) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL18048098 | 0.97 | ABCC4 (0.95) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL2322261 | 0.97 | ABCC4 (0.94) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL2322632 | 0.92 | ABCC4 (0.84) | ABCC4PDE4ATDP1HSD17B10NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 248 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4071477-B1 | COMPOSITIONS AND METHODS FOR DIAGNOSING LYME DISEASE AND FOR PREDICTING LYME DISEASE SPIROCHETE ELIMINATION AFTER TREATMENT | QIAGEN SCIENCES LLC (US) | 2026-01-21 | — | — | EP | claimed |
| EP-3452124-B1 | HEMOSTATIC DEVICES AND METHODS OF USE | MEDTRONIC INC (US) | 2025-10-08 | — | — | EP | claimed |
| EP-3452123-B1 | HEMOSTATIC DEVICES AND METHODS OF USE | MEDTRONIC INC (US) | 2025-09-24 | — | — | EP | claimed |
| EP-3230500-B1 | METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF | TEPHA INC (US) | 2025-06-18 | — | — | EP | claimed |
| CN-119859238-A | Bio-based chain extender and application thereof | 中国科学院宁波材料技术与工程研究所 | 2025-04-22 | — | — | CN | claimed |
| EP-3958889-B1 | COLLAGEN MIMETIC PEPTIDE COMPOSITIONS FOR TREATING A POSTERIOR SEGMENT OCULAR DISEASE OR DISORDER INVOLVING THE RETINA, RETINAL BLOOD VESSELS, RETINAL NERVES OR OPTIC NERVE | SUSTAIN HOLDINGS LLC (US) | 2025-01-08 | — | — | EP | claimed |
| EP-3678715-B1 | CALENDERED SURGICAL MESHES COMPRISING POLYHYDROXYALKANOATES | TEPHA INC (US) | 2024-10-30 | — | — | EP | claimed |
| EP-3802062-B1 | METHODS FOR 3D PRINTING OF POLY-4-HYDROXYBUTYRATE | TEPHA INC (US) | 2024-09-18 | — | — | EP | claimed |
| CN-118218413-A | Plate and strip thickness setting compensation method based on hybrid neural network | 河钢股份有限公司承德分公司 | 2024-06-21 | — | — | CN | claimed |
| CN-117773662-A | Flexible grinding and polishing cutter assembly for grinding and polishing structural parts and application method thereof | 成都飞机工业（集团）有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111487870-B | Design method of adaptive inversion controller in flexible active suspension system | 贵州理工学院 | 2022-09-16 | — | — | CN | claimed |
| CN-115052751-A | Printing press and method for operating a printing press | 博斯特比勒费尔德有限公司 | 2022-09-13 | — | — | CN | claimed |
| EP-3512851-B1 | BETA-LACTAMASE INHIBITOR COMPOUNDS | ENTASIS THERAPEUTICS LTD (GB) | 2022-07-06 | — | — | EP | claimed |
| CN-114559282-A | Numerical control machine tool capable of automatically changing tools based on big data | 刘建 | 2022-05-31 | — | — | CN | claimed |
| CN-114204860-A | Three-phase inverter control method and system based on virtual synchronous power generation technology | 国网山东省电力公司电力科学研究院 | 2022-03-18 | — | — | CN | claimed |
| WO-2022047047-A1 | INHALABLE THERAPEUTIC AGENTS | CILA THERAPEUTIC INC. (US) | 2022-03-03 | — | — | WO | claimed |
| CN-112590774-B | Intelligent electric automobile drifting and warehousing control method based on deep reinforcement learning | 同济大学 | 2022-02-18 | — | — | CN | claimed |
| CN-113988202-A | Mechanical arm abnormal vibration detection method based on deep learning | 季华实验室 | 2022-01-28 | — | — | CN | claimed |
| CN-113704930-B | Three-dimensional large-echelon space arrangement design method for shield cutter | 北京城建集团有限责任公司 | 2022-01-25 | — | — | CN | claimed |
| CN-101703448-A | Direct compression process for cefuroxime axetil dispersible tablets | SHANDONG ZIBO XINCAT PHARMACEU | 2010-05-12 | — | — | CN | claimed |