Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefuroxime Axetil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | PGR | P06401 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.50 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefuroxime Axetil SCHEMBL6859269 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL41099 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL379336 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL13575811 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL721709 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL10556419 | 1.00 | ABCC4 (1.00) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL2221553 | 0.97 | ABCC4 (0.95) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL18048098 | 0.97 | ABCC4 (0.95) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL2322261 | 0.97 | ABCC4 (0.94) | ABCC4PDE4ATDP1HSD17B10NR1I2 | |
| Cefuroxime Axetil SCHEMBL2322632 | 0.92 | ABCC4 (0.84) | ABCC4PDE4ATDP1HSD17B10NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001092309-A2 | HUMAN BETA-DEFENSIN-3 (HBD-3), A HIGHLY CATIONIC BETA-DEFENSIN ANTIMICROBIAL PEPTIDE | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2001-12-06 | — | — | WO | disclosed |