SCHEMBL7217326

SCHEMBL7217326

NC(=O)OCC(F)(COC(N)=O)c1ccc(F)cc1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 8/20 0.48
HSD11B1 P28845 2/20 0.38
KIF11 P52732 1/20 0.38
KCNE1 P15382 1/20 0.37
KCNQ1 P51787 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALDH1A1 P00352 1/20 0.36
PLOD2 O00469 1/20 0.36
PAX8 Q06710 1/20 0.36
RORC P51449 1/20 0.36
MAOB P27338 1/20 0.35
PARP10 Q53GL7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7217207 0.93 KCNN4 (0.46) KCNN4HSD11B1KIF11KCNE1KCNQ1
SCHEMBL7216196 0.84 NPSR1 (0.44) KCNN4KMT2ASMN1; SMN2ALDH1A1
SCHEMBL27898832 0.81 GRIN2D (0.49) KCNN4HSD11B1MEN1KMT2ASMN1; SMN2
SCHEMBL7212505 0.77 NPSR1 (0.42) KCNN4KIF11KMT2ASMN1; SMN2ALDH1A1
SCHEMBL28515506 0.70 MEN1 (0.39) KCNN4MEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL12833811 0.69 KCNN4 (0.55) KCNN4HSD11B1KIF11KCNE1KCNQ1
SCHEMBL5762294 0.69 MAOB (0.54) MEN1KMT2ASMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL11091284 0.69 KCNN4 (0.65) KCNN4KIF11KCNE1KCNQ1MEN1
SCHEMBL5112000 0.68 KCNN4 (0.59) KCNN4HSD11B1KCNE1KCNQ1MEN1
SCHEMBL969952 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1156798-B1 FELBAMATE DERIVED COMPOUNDS UNIV VIRGINIA (US) 2003-07-09 EP claimed