Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 10/20 | 0.55 |
| ▸ | RARB | P10826 | 10/20 | 0.55 |
| ▸ | RARG | P13631 | 10/20 | 0.55 |
| ▸ | RXRA | P19793 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669879 | 0.84 | RARB (0.59) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL7714814 | 0.80 | RARB (0.62) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL19034092 | 0.79 | RARA (0.51) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL8293245 | 0.76 | RARA (0.47) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL10976941 | 0.75 | RARB (0.76) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9142973 | 0.75 | RARB (0.80) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL10976930 | 0.75 | RARB (0.76) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9188112 | 0.75 | RARA (0.49) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL13708653 | 0.75 | RARA (0.46) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9054284 | 0.75 | RARA (0.46) | RARARARBRARGRXRACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627652-B1 | Treatment of diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid | ALLERGAN, INC. | 2003-09-30 | — | — | US | disclosed |
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5455265-A | For mammals; skin disorders, cancer, inflammatory disease, cardiovascular diorders, autoimmune diseases and others | ALLERGAN, INC. (US) | 1995-10-03 | — | — | US | disclosed |