Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.67 |
| ▸ | PARP1 | P09874 | 8/20 | 0.56 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23721287 | 0.82 | SLC2A1 (0.55) | SLC2A1PARP1IP6K1CHEK1PIM1 | |
| SCHEMBL28102830 | 0.81 | IP6K1 (0.60) | SLC2A1PARP1IP6K1ROCK2MAPT | |
| SCHEMBL11580425 | 0.80 | QPCT (0.63) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL6886187 | 0.78 | PARP1 (0.63) | SLC2A1PARP1IP6K1CHEK1PIM1 | |
| SCHEMBL839649 | 0.77 | KDM4E (0.54) | ROCK2KDM4EMAPTMEN1NPC1 | |
| SCHEMBL28592270 | 0.77 | SLC2A1 (0.49) | SLC2A1PARP1IP6K1CHEK1PIM1 | |
| SCHEMBL30506353 | 0.77 | SLC2A1 (0.49) | SLC2A1PARP1IP6K1CHEK1PIM1 | |
| SCHEMBL25305113 | 0.77 | SLC2A1 (0.49) | SLC2A1PARP1IP6K1CHEK1PIM1 | |
| SCHEMBL7217495 | 0.77 | KDM4E (0.52) | CHEK1ROCK2KDM4EKMT2AALOX15 | |
| Hydrochloric Acid SCHEMBL2397058 | 0.76 | KDM4E (0.53) | ROCK2KDM4EMAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| US-5679683-A | USEFUL FOR TREATING CANCER, ARTHRITIS, PSORIASIS, VASCULAR RESTENOSIS AND ANGIOGENESIS | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |